TABLE 1

Treatment groups, administered doses and collected samples in rats and dogs

Route of AdministrationDoseTreatment GroupRatDog
Radioactivity in DoseDose VolumeNo. of AnimalsSamples CollectedRadioactivity in DoseDose VolumeNo. of AnimalsSamples Collected
mg/kgμCi/mlml/kgμCi/mlml/kg
s.c.3LDC750.56Plasma, lymph, urine, feces100.54Plasma, lymph, urine
Control750.53Plasma, urine, feces100.52Plasma, urine
i.v.1LDC750.58Plasma, lymph, urine, feces100.54Plasma, lymph, urine
Control750.56Plasma, urine, feces100.52Plasma, urine