Kinetic parameters of terfenadine and astemizole metabolism using recombinant enzyme or cardiomyocytes
| Km | Vmax | |
|---|---|---|
| μM | pmol/pmol 2J2 per min | |
| Recombinant CYP2J2 terfenadine hydroxylation | 1.6 (±0.2) | 29.4 (±0.9) |
| Human cardiomyocyte terfenadine hydroxylation | 1.5 (±0.2) | 6.0 (±0.2) |
| Human cardiomyocyte astemizole demethylation | 5.2 (±0.7) | 3.2 (±0.1) |