In vitro stability of GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes
t1/2 Values are a mean of two independent incubations with individual replicate values in parentheses.
| Compound | Hepatocyte Species | t1/2 | CLint,app |
|---|---|---|---|
| min | µl min−1 million cells−1 | ||
| GLP-1(9-36)amide | Human | 180 (200,150) | 8.2 |
| Mouse | 52 (48,56) | 27 | |
| GLP-1(28-36)amide | Human | 24 (24,24) | 57 |
| Mouse | 13 (12,13) | 110 |