Relative abundance of urinary, biliary, and fecal metabolites of BIIB021 in rats and dogs after oral administration of [14C]BIIB021 (% of total administrated dose)
| Metabolite | Rat | Dog | ||||
|---|---|---|---|---|---|---|
| Urine | Feces (Bile) | Total | Urine | Feces | Total | |
| BIIB021 | ND | 0.92 (0.29) | 0.92 | 0.10 | 1.08 | 1.18 |
| M1 | ND | 6.06 | 6.06 | |||
| M2 | 1.38 | 7.51 (1.32) | 8.89 | 1.95 | 10.8 | 12.8 |
| M3 | 1.27 | 3.07 (4.65) | 4.34 | 1.12 | 1.08 | 2.20 |
| M4 | 1.04 | (10.8) | 1.04 | 15.0 | 15.0 | |
| M5 | 0.87 | 2.81 (1.26) | 3.68 | 0.12 | 0.12 | |
| M6 | 1.20 | 3.18 (1.86) | 4.38 | 2.50 | 1.50 | 4.00 |
| M7 | 14.2 | 15.6 (10.2) | 29.8 | 1.85 | 11.6 | 13.4 |
| M8 | (2.47) | |||||
| M9 | 0.28 | (0.66) | 0.28 | |||