Comparison between observed and predicted concentrations of paroxetine in maternal and umbilical venous plasma at delivery
| No. | Daily Dose | Duration of Paroxetine Treatment | Time of Delivery after Last Dose of Paroxetine | Observed Values at Delivery* | Model-Predicted Values | ||||
|---|---|---|---|---|---|---|---|---|---|
| Maternal Concentration | Umbilical Venous Concentration | Umbilical Venous-to -Maternal Ratio | Maternal Concentration | Umbilical Venous Concentration | Umbilical Venous-to -Maternal Ratio | ||||
| mg | h | ng/ml | ng/ml | ||||||
| 1 | 10 | wk 12– | 6 | 59 | 24 | 0.407 | 16.1 | 4.31 | 0.267 |
| 2 | 20 | wk 15– | 21 | 34 | 31 | 0.912 | 24.2 | 11.8 | 0.486 |
| 3 | 25 | wk 10– | 13 | 10 | 6 | 0.600 | 47.9 | 19.0 | 0.397 |
| 4 | 40 | Throughout pregnancy | 13 | 38 | 24 | 0.632 | 85.8 | 33.8 | 0.394 |
| 5 | 15 | wk 1–5, 16– | 19 | 22 | <1 | <0.05 | 16.9 | 8.14 | 0.483 |
↵* Hendrick et al., 2003.