Effect of MRP1 modulators on ATP-dependent vesicular uptake of E217βG by A989T and C1047S mutant MRP1
The values shown represents the mean IC50 values ± S.D. obtained from three independent experiments performed using two different preparations of membrane vesicles.
| IC50 (µM) | |||
|---|---|---|---|
| Wild-Type | A989T | C1047S | |
| LY465803 (+ GSH) | 0.07 ± 0.01 | 0.05 ± 0.01 | 0.03 ± 0.03 |
| BAYu9773 | 0.62 ± 0.16 | 0.32 ± 0.19 | 0.69 ± 0.18 |
| LY171883 | 16.10 ± 1.28 | 19.58 ± 6.15 | 23.90 ± 9.85 |