Plasma exposure of [3H]MRL-1 radioactivity in LDC rats and dogs
| Dose | Group | Rat | Dog | ||
|---|---|---|---|---|---|
| AUC0–168 h | % of Control | AUC0–120 h | % of Control | ||
| µM·h | µM·h | ||||
| s.c. (3 mg/kg) | LDC | 7.7 ± 2.5 | 44 | 6.4 ± 5.6 | 18 |
| Control | 17.4 ± 2.2 | 100 | 35.2 | 100 | |
| i.v. (1 mg/kg) | LDC | 4.4 ± 0.8 | 70 | 32.3 ± 4.5 | 84 |
| Control | 6.3 ± 0.5 | 100 | 38.6 | 100 | |