Cumulative recovery of [3H]MRL-1 related radioactivity (percentage of dose) from lymph, urine, and feces in rats and dogs.
| Dose | Group | Percentage of Administered Dose Recovered | ||||||
|---|---|---|---|---|---|---|---|---|
| Rat | Dog | |||||||
| Lymph | Urine | Feces | Total | Lymph | Urine | Total | ||
| s.c. (3 mg/kg) | LDC | 26.7 ± 9.0 | 19.1 ± 1.8 | 5.6 ± 3.9 | 51.4 | 72.9 | 6.7 | 79.6 |
| Control | — | 29.8 ± 0.4 | 8.6 ± 6.4 | 38.4 | — | — | — | |
| i.v. (1 mg/kg) | LDC | 26.4 ± 3.6 | 30.5 ± 14.9 | 4.6 ± 2.9 | 61.5 | 20.3 ± 6.1 | 47.6 | 67.9 |
| Control | — | 57.3 ± 22.0 | 8.0 ± 2.0 | 65.3 | — | 48.1 | 48.1 | |