TABLE 4

Pharmacokinetics of GDC-0917 in cancer patients given a 5-mg starting dose

ParametersCmaxtmaxaAUCinft1/2
ng/mlhng/ml× hh
Observed4.57 ± 1.672–637.1 ± 25.43.98 ± 1.56
Predicted4.372.446.46.70

  • ↵a Observed tmax is presented as a range.