TABLE 3

Pharmacokinetic data in humans and rats as used in the PBPK modeling

Rat and human PK data are from the literature (Supplemental Table 1).

CompoundHumansRatsUrinary Excretion in HumansBlood/Plasma Ratio
Dose (i.v./oral)fupDose (i.v./oral)fupa
mgmg% of dose
Alprazolam1/10.29b0.467/2.67NA20c0.85d
AtorvastatinNANA0.55/2.750.045NA0.61e
Buspirone1/200.050f0.289/0.9640.208<0.1c0.81e
Cyclosporine A111/3720.068b1.13/1.13NA<1c1.36e
Erythromycin500/5000.1bNANANANA
Felodipine3/150.004cNANA<1c0.70e
IndinavirNANA1.75/70.360bNA0.84e
Midazolam5/100.020c2.25/3.380.046<10.75e
Nifedipine1.46/200.0581.65/1.680.0330c0.67d
Paracetamol1000/5000.75b33.3/33.30.492NANA
Saquinavir12/6000.020gNANANA0.74e
Sildenafil50/500.0652.82/8.970.103NA0.64d
Tacrolimus1.55/3.880.012h0.425/2.13NANA35e
TerfenadineNA/600.01NA<0.05NA1e
Triazolam0.25/0.250.145NANANA0.62d
Verapamil10/1200.1051.18/1.180.153NA0.89d
  • NA, not applicable.

  • a When no data were available for fup in rat plasma, the corresponding value in humans was used.

  • b Data are from Obach et al., 2008.

  • c Data are from Goodman et al., 2006.

  • d Data are from Gertz et al., 2010.

  • e Data are from Gertz et al., 2011.

  • f Data are from Gammans et al., 1986.

  • g Data are from Wishart et al., 2008.

  • h Data are from Zahir et al., 2001.