Criteria for BBB class assignment Comparison of criteria for BBB class assignment (BBB+ drugs). See text for details.
| Criteria for BBB+ drugs (i.e., “good” CNS penetration.) | ||
|---|---|---|
| Broccatelli et al. | Kikuchi et al. | |
| Marketed CNS agents | Yes | Can be misleading |
| Unbound brain-to-plasma ratio | >0.1 | >0.33 |
| Unbound CSF-to-plasma ratio | >0.1 | Can be misleading |
| In vivo P-gp ER | Not considered | <3.0 |