Pharmacokinetic parameters of tacrolimus (FK506) after a single oral dose of tacrolimus (1.89 mg/kg) in rats with and without an oral dose of lignans (0.024 mM/kg). Data are the mean ± S.D. (n = 5).
| Group | Parameters of FK506 | |||||||
|---|---|---|---|---|---|---|---|---|
| Cmax | Tmax | t1/2 | MRT | Vd/F | CL/F | AUC0-24h | AUC0-∞ | |
| ng/ml | h | h | h | l/kg | l/h/kg | ng × h/ml | ng × h/ml | |
| Con. | 15.1 ± 11.2 | 0.9 ± 0.8 | 6.7 ± 1.9 | 5.7 ± 1.4 | 308.2 ± 157.5 | 30.0 ± 11.9 | 57.7 ± 31.1 | 67.7 ± 34.9 |
| + Schisantherin A | 31.2 ± 13.9 | 1.9 ± 1.9 | 8.6 ± 2.6 | 6.4 ± 0.7 | 144.1 ± 53.5 | 11.9 ± 4.5 | 143.2 ± 50.1 | 175.7 ± 59.4 |
| + Schisandrin A | 39.8 ± 30.0 | 1.6 ± 1.0 | 6.5 ± 2.7 | 4.8 ± 0.8 | 157.5 ± 75.3 | 19.1 ± 13.5 | 137.3 ± 131.1 | 170.6 ± 155.9 |
| + Schisandrin B | 24.8 ± 14.3 | 1.4 ± 1.5 | 8.9 ± 2.0 | 7.1 ± 0.6 | 194.7 ± 96.3 | 14.9 ± 6.1 | 110.7 ± 46.3 | 141.9 ± 46.9 |
| + Schisandrin C | 21.1 ± 15.2 | 1.5 ± 1.6 | 8.4 ± 1.9 | 5.6 ± 0.6 | 252.5 ± 68.7 | 21.7 ± 8.6 | 73.5 ± 36.2 | 99.1 ± 39.8 |
| + Schisandrol A | 13.1 ± 4.8 | 2.5 ± 1.1 | 7.9 ± 1.7 | 5.9 ± 1.2 | 240.9 ± 63.1 | 22.8 ± 12.0 | 72.3 ± 26.4 | 95.7 ± 30.6 |
| + Schisandrol B | 78.4 ± 16.1 | 2.0 ± 1.5 | 5.9 ± 2.1 | 5.7 ± 0.5 | 51.3 ± 56.7 | 5.1 ± 3.4 | 447.5 ± 207.6 | 472.8 ± 202.8 |
CL/F, blood clearance of oral doses; Con., Control group (FK506 alone); MRT, mean residence time; t1/2, terminal half-life; Tmax, time to peak blood concentration; Vd/F, apparent volume of distribution of oral doses.