TABLE 4

Frequency of OATP1B1, OATP1B3, and P-gp SNPs detected in the University of Washington (UW) liver bank

Marker IDVariantChange for VariantFrequency in UW liver Bank
Homozygous VariantHeterozygous VariantWild-Type
OATP1B1
 rs4149015−11187G>APromoter0953
 rs2306283388A>GN130D103022
 rs11045819463C>AP155T4949
 rs4149056521T>CV174A12140
 rs4149057571T>CL191L163412
 rs2291075597C>TF199F103319
OATP1B3
 rs4149117334G>TA112S04517
 rs7311358699A>GI233M04517
 rs20530981557G>AA519A04517
 rs37640061833A>GG611G04220
P-gp
 rs2214102−1G>A5′UTR0656
 rs2235015287-25G>TIntron01943
 rs10276036IVS9-44A>GIntron193112
 rs11285031236C>TG412G183311
 rs20325881350+44C>TIntron0755
 rs22350331554+24C>TIntron22328
 rs22350131725+38A>GIntron21338
 rs928256461A>GN21D71145
 rs22350402481+24G>AIntron01250
 rs20325822677G>T, 2677G>AA893S, A893T173213
 rs3213619−129T>C5′UTR0458
 rs10456423435C>TI1145I223010
 rs17064*89A>T3′UTR0755
 rs3842*193A>G3′UTR01844
  • OATP, organic anion-transporting polypeptide; P-gp, P-glycoprotein; SNP, single nucleotide polymorphisms; UW, University of Washington.

  • OATP2B1 SNPs, rs59305495, rs72559740, rs1109407, rs1621378, and rs2306167 were not found in the UW liver bank. All other SNPs available in the Affymetrix DMET Plus array for OATP1B1, OATP1B3, and P-gp were not observed.