TABLE 3

Multiple regression analysis of factors associated with plasma concentrations of 4β-hydroxycholesterol

Dependent/Explanatory VariableModel r2 or Partial r2P valueParameter Estimate
Plasma concentrations of 4β-hydroxycholesterol (ng/ml)0.524<0.0001
Number of CYP3A5*3 alleles0.346<0.0001−12.3
Plasma concentrations of 3-INDS (μM)0.1260.00415−0.404
Body weight (kg)0.0520.0233−0.296