Analyte and Strain | t1/2 | Tmax | Cmax | AUC0-8h | CL/F |
---|---|---|---|---|---|
h | h | μg/ml | μg*h/ml | ml/h | |
NA | |||||
WT | 1.0 ± 0.4 | 0.5 ± 0.1 | 2.2 ± 0.3 | 5.0 ± 1.6 | 940 ± 290 |
Cyp2a5-null | 0.8 ± 0.1 | 0.3 ± 0.1a | 2.7 ± 0.2 | 5.8 ± 1.6 | 800 ± 210 |
NA-GSH | |||||
WT | 0.8 ± 0.3 | 2.0 ± 0 | 4.4 ± 0.8 | 12.6 ± 3.3 | N/A |
Cyp2a5-null | 0.7 ± 0.1 | 1.4 ± 0.8 | 3.9 ± 1.5 | 10.6 ± 4.1 | N/A |
AUC0-8h, area under the concentration-time (0-8h) curve; CL, clearance; F, bioavailability; CL/F, total body clearance instead of CL, given that F is not known; N/A, not applicable.
↵a P < 0.01, Student’s t test, compared with corresponding WT values.