TABLE 3

Kinetic parameters of M2 formation from 2-oxo-ticlopidine by human cDNA-expressed CYP isoforms

CYP Isoform	K_m	V_max	CL_int	n^a
	μM	pmol/min/pmol CYP	μL/min/pmol CYP
CYP1A2	128	0.40	0.003	1.61
CYP2B6	0.59	0.73	1.24	1.69
CYP2C19	4.39	1.49	0.34	—
CYP2D6	22.6	2.50	0.11	—
CYP3A4	199	1.67	0.008	1.54