Fold Increase in Exposure (AUCi/AUC) | ||
---|---|---|
[I]in vivo | Equation Used to Estimate the [I]in vivo | 1 + ([I]in vivo/Ki) |
Systemic total Cmax | [I]in vivo = Cmax at steady state | 5.19 |
Systemic free Cmax | [I]in vivo = fu × Cmax at steady state | 1.17 |
Estimated total portal Cmax | [I]in vivo = Cmax + ka × Fa × D/Qh | 11.5 |
Estimated total free Cmax | [I]in vivo = fu × (Cmax + ka × Fa × D/Qh) | 1.42 |
D, dose of inhibitor; Fa, fraction absorbed from the gastrointestinal tract; fu, unbound fraction of sarpogrelate in plasma; [I], concentrations of sum of inhibitors; ka, absorption rate constant; Qh, human hepatic blood flow rate.