Comparison of genotype frequencies in 260 patients who developed acute liver failure either unintentionally from chronic acetaminophen use (n = 79), intentionally from acute acetaminophen overdose (n = 78), or from causes other than acetaminophen (n = 103)
| Genotype | Acetaminophen | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Unintentional | Intentional | Other causes | ||||||||
| n | (%) | P valuea | n | (%) | P valuea | n | (%) | P valuea | ||
| UGT1A-3′UTR | C/C | 56 | (71) | 0.027b 0.98 | 42 | (54) | 0.13, 0.48 | 60 | (58) | 0.50, 0.53 |
| rs8330 | C/G | 20 | (25) | 32 | (41) | 40 | (39) | |||
| G/G | 3 | (4) | 4 | (5) | 3 | (3) | ||||
| UGT1A1 (TA)n | 56/56 | 39 | (50) | 0.28, 0.71 | 42 | (54) | 0.064, 0.33 | 35 | (35) | 0.0066b 0.56 |
| 5or6->7or8 | 56/78 | 30 | (38) | 30 | (38) | 54 | (53) | |||
| 78/78 | 9 | (12) | 6 | (8) | 12 | (12) | ||||
| UGT1A6 | T/T | 32 | (41) | 0.13, 0.87 | 28 | (36) | 0.58, 0.67 | 26 | (27) | 0.050, 0.58 |
| rs6759892 | T/G | 35 | (44) | 38 | (49) | 55 | (56) | |||
| G/G | 12 | (15) | 11 | (14) | 17 | (17) | ||||
| UGT1A6 | A/A | 40 | (51) | 0.16, 0.38 | 36 | (47) | 0.57, 0.35 | 36 | (37) | 0.061, 0.94 |
| rs2070959 | A/G | 30 | (38) | 36 | (47) | 53 | (54) | |||
| G/G | 9 | (11) | 5 | (6) | 9 | (9) | ||||
| UGT1A6 | A/A | 37 | (47) | 0.23, 0.39 | 35 | (45) | 0.38, 0.19 | 33 | (34) | 0.049b 0.68 |
| rs1105879 | A/C | 32 | (41) | 37 | (48) | 54 | (55) | |||
| C/C | 10 | (13) | 5 | (6) | 11 | (11) | ||||
| UGT1A9 | T/T | 72 | (91) | 0.44 | 66 | (85) | 0.16 | 93 | (90) | 0.55 |
| rs6714486 | T/A | 7 | (9) | 12 | (15) | 10 | (10) | |||
| UGT2B15 | G/G | 21 | (30) | 0.62, 0.45 | 19 | (25) | 0.58, 0.06 | 27 | (28) | 0.95, 0.29 |
| rs1902023 | G/T | 36 | (51) | 34 | (45) | 52 | (53) | |||
| T/T | 14 | (20) | 23 | (30) | 19 | (19) | ||||
| SULT1A1 | G/G | 36 | (46) | 0.87, 0.64 | 34 | (44) | 0.89, 0.94 | 46 | (45) | 0.97, 0.61 |
| rs9282861 | G/A | 35 | (44) | 36 | (47) | 49 | (48) | |||
| A/A | 8 | (10) | 7 | (9) | 8 | (8) | ||||
| CYP2E1*1D | 6/6 | 75 | (96) | 0.83 | 77 | (99) | 0.21 | 98 | (95) | 0.32 |
| 6->8 repeats | 6/8 | 3 | (4) | 1 | (1) | 5 | (5) | |||
| CYP2E1*1x2 | 1/1 | 74 | (94) | 0.94, 0.13 | 74 | (95) | 0.65, 0.51 | 96 | (93) | 0.73, 0.42 |
| 1->2 copies | 1/2 | 4 | (5) | 4 | (5) | 7 | (7) | |||
| 2/2 | 1 | (1) | 0 | (0) | 0 | (0) | ||||
| CYP3A5 | G/G | 74 | (94) | 0.082 | 64 | (82) | 0.034b | 92 | (89) | 0.73 |
| rs776746 | G/A | 5 | (6) | 14 | (18) | 11 | (11) | |||
| CD44 | G/G | 51 | (65) | 0.21, 0.045b | 59 | (76) | 0.19, 0.75 | 72 | (70) | 0.98, 0.11 |
| rs1467558 | G/A | 23 | (29) | 17 | (22) | 30 | (29) | |||
| A/A | 5 | (6) | 2 | (3) | 1 | (1) | ||||
| BHMT1 | G/G | 34 | (43) | 0.56, 0.41 | 31 | (40) | 0.20, 0.10 | 54 | (52) | 0.081, 0.43 |
| rs3733890 | G/A | 37 | (47) | 33 | (42) | 38 | (37) | |||
| A/A | 8 | (10) | 14 | (18) | 11 | (11) | ||||
↵a P values are given for chi-square test of both dominant (left value) and recessive (right value) genetic models comparing differences in genotype numbers for the indicated ALF group with the summed genotype numbers for the other two ALF groups. Only one P value is listed for the UGT1A9, CYP2E1*1D, and CYP3A5 polymorphisms because no homozygous variant genotype individuals were found, so only the dominant model could be tested.
↵b P < 0.05.