Mean ± S.D. (range, i.e., maximum/minimum in parentheses) protein expression in human livers and human hepatocytes observed in this study (bolded) or reported by others
| No. of Samples | OATP1B1 | OATP1B3 | OATP2B1 | P-glycoprotein | Reference |
|---|---|---|---|---|---|
| Liver tissue (fmol/µg membrane protein) | |||||
| 64 (Peptide 1) | 2.0 ± 0.9 (7) | 1.1 ± 0.5 (8) | 1.7 ± 0.6 (5) | 0.4 ± 0.2 (8) | This study |
| 64 (Peptide 2) | NQ | 0.9 ± 0.4 (8) | 1.5 ± 0.6 (6) | 0.3 ± 0.2 (7) | This study |
| 17 | 2.7 ± 3.7* | 1.7 ± 0.5 | 0.5 ± 0.9 | 1.5 ± 0.4 | (Ohtsuki et al., 2012) |
| 9 | 9.7 ± 4.3 | 6.3 ± 2.8 | 3.7 ± 1.4 | NQ | (Kimoto et al., 2012) |
| 13 | NQ | NQ | NQ | 0.7 ± 0.3 | (Tucker et al., 2012) |
| 12 | 7.2 ± 0.3 | 6.3 ± 0.4 | 4.0 ± 0.4 | NQ | (Karlgren et al., 2012) |
| 4 | 10.6 ± 4.6 | 5.9 ± 3.8 | 2.9 ± 1.3 | NQ | (Balogh et al., 2012) |
| Cryopreserved suspended hepatocytes | |||||
| 12$ | 2.4 ± 0.5 (2) | 0.9 ± 0.5 (5) | 1.7 ± 0.5 (3) | 0.5 ± 0.1 (4) | This study |
| 12 | NQ | 0.7 ± 0.3 (4) | 1.3 ± 0.5 (3) | 0.4 ± 0.1 (4) | This study |
| 14 | 4.9 ± 1.9 | 1.7 ± 0.6 | 1.6 ± 0.5 | NQ | (Kimoto et al., 2012) |
| 1 | 5.8 | 5.8 | 4.1 | NQ | (Ji et al., 2012) |
| 1 | 3.4 | 1.5 | 1.8 | NQ | (Bi et al., 2012) |
| Sandwich-cultured hepatocytes | |||||
| 3 | 5.4 ± 1.0 | 4.3 ± 0.2 | 2.9 ± 2.5 | 13.9 ± 11.8 | (Schaefer et al., 2012) |
| 5 | 5.8 ± 3.3 | 0.8 ± 0.3 | 1.0 ± 0.2 | NQ | (Kimoto et al., 2012) |
| 1 | 5.3 | 0.9 | 1.2 | NQ | (Bi et al., 2012) |
NQ, not quantified.
↵* OATP1B1 was detected in only eight liver tissue samples.
$ Seven batches of individual and five batches of pooled hepatocytes (see Table 2).