TABLE 1

Physical and chemical properties of navitoclax and ABT-199

	Navitoclax	ABT-199
Molecular weight (Da)	974	868
TPSA	128	172
cLogP^{^a}	9.7	8.1
eLogD_pH7.4^{^b}	6.3	5.4
Melting point (°C)	120	136
Soybean oil solubility /LCT (mg/ml)	9.17	2.24
Aqueous solubility; pH 1, 7.4, Fasted SSIF, fed SSIF (mg/ml)	<0.0002, <0.0002, 0.081, 0.110	0.0023, <0.0004, 0.011, 0.010

↵^a cLogP calculated using ACDLabs Ver. 11 software.
↵^b Experimentally determined using HPLC retention technique modified from EPA method.