UGT1A7 allozymes | Km | Vmax | Vmax/Km |
---|---|---|---|
µM | pmol/min/mg protein | ||
4-MUa | |||
*1 | 43.2 ± 3.0 | 46.5 ± 1.6 | 1.08 |
*1+CYP3A4 | 50.3 ± 3.2 | 72.6 ± 2.4$$ | 1.44 |
*2 | 34.1 ± 3.5¶ | 31.8 ± 1.5¶¶ | 0.93 |
*2+CYP3A4 | 26.8 ± 2.5 | 74.2 ± 3.0$$ | 2.76 |
*3 | 45.5 ± 6.4 | 56.8 ± 4.0¶¶ | 1.25 |
*3+CYP3A4 | 47.9 ± 2.2 | 32.5 ± 0.8$$ | 0.68 |
SN-38b | |||
*1 | 9.72 ± 2.37 | 1.52 ± 0.13 | 0.157 |
*1+CYP3A4 | 13.81 ± 0.94 | 1.85 ± 0.05$ | 0.134 |
*2 | 7.95 ± 2.08 | 0.97 ± 0.08¶¶¶ | 0.123 |
*2+CYP3A4 | 6.13 ± 1.04 | 2.37 ± 0.12$$$ | 0.386 |
*3 | 9.80 ± 2.03 | 1.30 ± 0.10 | 0.133 |
*3+CYP3A4 | 8.68 ± 1.03 | 0.93 ± 0.04$$$ | 0.107 |
4-OHBPc | |||
*1 | 679 ± 46 | 11.6 ± 0.4 | 0.017 |
*1+CYP3A4 | 613 ± 42 | 14.9 ± 0.5$$$ | 0.024 |
*2 | 784 ± 102 | 10.9 ± 0.7 | 0.014 |
*2+CYP3A4 | 642 ± 70 | 23.9 ± 1.2$$$ | 0.037 |
*3 | 638 ± 45 | 12.5 ± 0.4¶¶ | 0.020 |
*3+CYP3A4 | 716 ± 75 | 7.0 ± 0.3$$$ | 0.010 |