Metabolite | RT | Identity | MH+ | MSn Spectral Data | Racemic Amlopdipine | S-amlodipine |
---|---|---|---|---|---|---|
min | ||||||
M1 | 10.06 | P-2H-CH2 | 393 | MS2: 376, 350, 332, 314, 304; | √ | − |
MS3 (332): 304, 286 | ||||||
M3 | 11.79 | P + O | 425 | MS2: 379, 336, 294, 364; | √ | √ |
MS3 (336): 318, 304, 180 | ||||||
M4 | 12.02 | P-2H-C2H4NH-C2H4 | 336 | MS2: 318,286; | √ | √ |
MS3 (318): 286 | ||||||
M5 | 12.06 | P + O | 425 | MS2: 417, 390, 379, 336, 294; | √ | √ |
MS3 (336): 318,304,286,181 | ||||||
M6 | 12.06 | P-CH2 | 395 | MS2:352, 334, 306,180; | √ | − |
MS3 (180): 163,144 | ||||||
M8 | 12.71 | P + O | 425 | MS2: 390, 379, 336, 294, 364; | √ | √ |
MS3 (336): 318, 304, 248,181 | ||||||
M9 | 13.57 | P-2H | 407 | MS2: 390, 364, 346, 318, 286; | √ | √ |
MS3 (346): 318, 286. | ||||||
M10 | 17.88 | P-2H-NH+O | 408 | MS2: 346,318, 286, 390; | √ | √ |
MS3 (346): 318, 286 | ||||||
M12 | 18.38 | P-2H-NH+2O-2H | 422 | MS2: 376, 346, 318, 286; | √ | √ |
MS3 (346): 318, 286 | ||||||
P | 15.02 | Amlodipine | 409 | MS2: 392, 346, 348, 320, 294, 238; | √ | √ |
MS3 (392): 360, 346 |
MH+, protonated molecular ions; MSn, multiple stage MS/MS fragmentation; RT, retention time.