Drug | Conc. Range Used | IC50 Value | [I]2/IC50 for Dabigatran Etexilate | AUCi/AUC of Dabigatran |
---|---|---|---|---|
μM | μM | |||
Amiodarone | 1–10 | >10 | <470 | 1.6a |
Clarithromycin | 0.3–30 | 28 | 36 | 1.2a |
Cyclosporine A | 0.1–12 | 0.69 | 240 | |
Digoxin | 1–100 | 125 | 0.0080 | 1.1b |
Itraconazole | 0.3–10 | 0.41 | 1100 | |
Ketoconazole | 0.1–6 | 3.4 | 880 | 2.5a |
Nelfinavir | 0.3–10 | 3.6 | 2100 | |
Quinidine | 1–60 | 33 | 150 | 1.6a |
Ritonavir | 0.3–30 | 13 | 260 | |
Tacrolimus | 0.1–6 | 0.66 | 74 |
↵a Pradaxa package insert, 2010; bStangier et al., 2011.