Comparison of the contribution of CYP3A4 versus CYP3A5 to the formation of M2a and M2b
| Metabolite Formation rate in rCYP3A4: Metabolite Formation Rate in rCYP3A5 (at the Same Cytochrome P450 Content, 208 pmol/ml) | |||||
|---|---|---|---|---|---|
| M2a | M2b | ||||
| 1.4: 1 | 27: 1 | ||||
| CYP3A5 Allelic Variants | Frequency (Lin et al., 2002) | Contribution of CYP3A4:CYP3A5, Normalized by Relative Content of CYP3A4 and CYP3A5 in Subjects with Different CYP3A5 Allelic Variants | Ratio of Formation Rates for M2a Versus M2b, Normalized by Relative Content of CYP3A4 and CYP3A5 in Subjects with Different CYP3A5 Allelic Variants | ||
| M2a | M2b | M2a:M2b | |||
| *1/*1 | 1.7% | 30: 70 | 89: 11 | 1: 0.51 | |
| *1/*3 | 22% | 58: 42 | 96: 4 | 1:0.92 | |
| *3/*3 | 77% | 97: 3 | 99.8: 0.2 | 1:1.5 | |