TABLE 3

Age-dependent changes in mRNA expression of CES isozymes in liver from rats of different ages

Each value shows the mean ± S.D. (n = 4). *P < 0.05 and **P < 0.01 indicate statistically significant differences compared with the 8-week-old age group.

CES isozymes		Fold Change^a
CES isozymes		8 Weeks	46 Weeks	90 Weeks
CES1 family	Hydrolase A	1.03 ± 0.100	1.10 ± 0.304	0.418 ± 0.115**
	Egasyn	0.0811 ± 0.349	0.0837 ± 0.0231	0.0613 ± 0.0148
	Hydrolase B/C	1.41 ± 0.407	0.561 ± 0.141*	0.325 ± 0.0657**
	Hydrolase S	2.50 ± 0.352	1.43 ± 0.433*	0.756 ± 0.216**

CES2 family	RL4/AB010632	0.0311 ± 0.0103	0.0705 ± 0.0256	0.0528 ± 0.0142
	AY034877	0.110 ± 0.0242	0.0843 ± 0.00160	0.0869 ± 0.0406
	D50580	0.0629 ± 0.0244	0.0197 ± 0.0220	0.0134 ± 0.0229*

↵^a Fold change: the change in expression of the CES mRNA relative to GAPDH mRNA.