Matrix | Species | Cofactor | M9 | M13 | M18 |
---|---|---|---|---|---|
Liver microsomes | Rat | +N | − | − | − |
Dog | +N | − | − | − | |
Monkey | -N | − | − | − | |
+N | + | − | + | ||
+N+ABT | − | − | − | ||
Human | +N | − | − | − | |
HepatoPac | Rat | NA | − | − | − |
Dog | NA | − | − | − | |
Monkey | NA | − | − | + | |
Human | NA | − | − | + |
−, No formation of metabolite; +, formation of metabolite; ABT, 1-aminobenzotriazole; +N, with NADPH; −N, without NADPH; NA, not applicable.