Generation of the cleaved metabolites M9, M13, and M18, from incubations of vismodegib with liver microsomes, hepatocytes, and HepatoPac from various species
| Matrix | Species | Cofactor | M9 | M13 | M18 |
|---|---|---|---|---|---|
| Liver microsomes | Rat | +N | − | − | − |
| Dog | +N | − | − | − | |
| Monkey | -N | − | − | − | |
| +N | + | − | + | ||
| +N+ABT | − | − | − | ||
| Human | +N | − | − | − | |
| HepatoPac | Rat | NA | − | − | − |
| Dog | NA | − | − | − | |
| Monkey | NA | − | − | + | |
| Human | NA | − | − | + |
−, No formation of metabolite; +, formation of metabolite; ABT, 1-aminobenzotriazole; +N, with NADPH; −N, without NADPH; NA, not applicable.