TABLE 2

Major collision-induced product ions of vismodegib and the stable-labeled vismodegib and their pyridine cleaved metabolites in feces of rats dosed orally with 50 mg/kg

Analyte	[M + H]⁺	Major Fragment Ions^{^a}
	m/z	m/z
Vismodegib	421	342 (100), 313, 306, 217, 188, 155, 139
Labeled vismodegib	424	345 (100), 316, 309, 217, 191, 155, 139
M9	443	426 (100), 398, 380, 217, 155
Labeled M9	445	427 (100), 399, 381, 217, 155
M13	444	426 (100), 398, 380, 362, 301, 217, 155
Labeled M13	445	427 (100), 399, 381, 217, 155
M18	471	453 (100), 443, 426, 425, 397
Labeled M18	474	456 (100), 445, 427, 399

↵a Each base peak is labeled as 100 in parentheses.