TABLE 3

Plasma, brain, and CSF AUC and their unbound ratios (mean and S.D.) after cassette dosing in wild-type and Mdr1a knockout rats from study 2

	Wild-Type Rats						Mdr1a Knockout Rats
Compound	AUC_p	AUC_b	AUC_CSF	K_p,uu,brain	K_p,uu,CSF	C_ub/C_CSF	AUC_p	AUC_b	AUC_CSF	K_p,uu,brain	K_p,uu,CSF	C_ub/C_CSF
	ng⋅h/ml						ng⋅h/ml
Amprenavir	267	6.34	7.27	0.016	0.27	0.062	366	108	11.7	0.20	0.31	0.65
S.D.	37	4.98	2.89	0.014	0.12	0.055	81	23	4.2	0.08	0.14	0.30
Citalopram	43.1	233	8.13	0.72	0.81	0.88	50.7	880	20.3	2.3	1.7	1.3
S.D.	10.2	46	1.76	0.23	0.26	0.27	10.0	120	7.4	0.6	0.7	0.5
Digoxin	1580	41.5	29.3	0.015	0.065	0.23	1870	853	178	0.255	0.331	0.772
S.D.	320	30.9	6.7	0.011	0.021	0.18	380	105	54	0.067	0.127	0.255
Elacridar	0.886	1.28	BLLOQ	0.39	NA	NA	0.372	2.60	BLLOQ	1.9	NA	NA
S.D.	0.289	0.26	NA	0.30	NA	NA	0.174	1.13	NA	1.7	NA	NA
Imatinib	126	6.70	1.34	0.14	0.54	0.26	151	25.5	3.21	0.44	1.1	0.41
S.D.	42	2.24	0.48	0.07	0.26	0.13	24	3.4	0.90	0.09	0.3	0.13
Ko143	BLLOQ	BLLOQ	BLLOQ	NA	NA	NA	BLLOQ	BLLOQ	BLLOQ	NA	NA	NA
S.D.	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Loperamide	38.6	3.59	0.204	0.013	0.12	0.11	30.0	38.6	1.02	0.18	0.79	0.23
S.D.	5.6	1.12	0.280	0.005	0.17	0.15	4.7	4.5	0.31	0.04	0.28	0.08
Prazosin	140	26.5	4.08	0.092	0.13	0.71	170	60.1	12.7	0.17	0.33	0.51
S.D.	32	5.4	1.42	0.030	0.05	0.29	22	5.9	2.9	0.03	0.09	0.14
Quinidine	148	29.9	8.85	0.038	0.22	0.17	182	1980	47.4	2.0	0.94	2.14
S.D.	23	5.0	2.68	0.013	0.07	0.07	32	230	12.2	0.7	0.30	0.81
Sulfasalazine	393	BLLOQ	BLLOQ	NA	NA	NA	437	BLLOQ	BLLOQ	NA	NA	NA
S.D.	47	NA	NA	NA	NA	NA	101	NA	NA	NA	NA	NA
Verapamil	155	74.3	5.54	0.18	0.59	0.31	182	1620	18.5	3.4	1.7	2.0
S.D.	21	16.8	1.92	0.05	0.22	0.13	32	330	7.6	1.0	0.8	0.9

BLLOQ, below the lower limit of quantitation; NA, not applicable.