ABCB11 | ABCC2 | ABCB1 | ABCG2 | ABCB4 | ABCG5/G8 |
---|---|---|---|---|---|
Endogenous substrates | |||||
Glycocholic acida | Bilirubin mono- and diglucuronidea | Aldosteronea | Cholic acida | Phosphatidylcholinea | Cholesterola |
Taurocholic acida | Cholecystokinin-8-sulfatea | Cholesterola | Estradiol-17β-glucuronidea | ||
Glycochenodeoxycholic acida | Estradiol-17β-glucuronidea | Cortisola | Estrone-3-sulfatea | ||
Taurochenodeoxycholic acida | Estrone-3-sulfatea | Estradiol-17β-glucuronidea | Folic acid glutamatesa | ||
Glycodeoxycholic acida | Glutathione disulfidea | Estronea | Glycocholic acida | ||
Taurodeoxycholic acida | Hyodeoxycholic acid glucuronidea | Ethinylestradiola | Hemea | ||
Tauroursodeoxycholic acida | Leukotriene C4a | Opioid peptidesa | Protoporphyrin IXa | ||
Taurolithocholate-3-sulfatea | Prostaglandin E2a | Short-chain phospholipidsa | Taurocholic acida | ||
Taurolithocholatic acid sulfatea | Unconjugated bilirubina | Taurolithocholic acid sulfatea | |||
Tauroursodeoxycholic acida | 6α-OH-taurocholic acid | Uratea | |||
6α-OH-taurocholic acid | |||||
Exogenous substrates | |||||
Calcein-AM | Acetaminophen glucuronide | Calcein-AMa | 4-Methylumbelliferone glucuronidea | Digoxina | 24-Methylene cholesterola |
Pravastatina | Acetaminophen glutathione | Colchicine | 4-Methylumbelliferone sulfatea | Paclitaxela | Brassicasterola |
Taxol | Acetaminophen sulfate | Daunorubicina | Albendazole sulfoxidea | Vinblastinea | Campesterola |
Vinblastine | Ampicillin | Digoxina | Anthracenesa | 5α-Campestanola | |
Arsenitea | Diltiazema | Anthracyclinesa | 5α-Cholestanola | ||
Bromosulfophthalein glutathionea | Docetaxela | Camptothecin derivatesa | 22-Dehydrocholesterola | ||
Cadmiuma | Doxorubicina | Daunomycina | Sitosterola | ||
Carboxydichlorofluorescein-diacetate | Erythromycina | Dinitrophenyl glutathionea | 5α-Sitostanola | ||
Ceftriaxone | Ethidium bromidea | Doxorubicina | Stigmasterola | ||
Dibromosulfophthalein | Etoposidea | E3040-glucuronide | |||
Dinitrophenyl glutathionea | Gramicidin Da | Hoechst 33342a | |||
Indomethacin glucuronide | Hoechst 33342a | Irinotecan (SN-38 metabolite)a | |||
Methotrexatea | Indinavir | Imatiniba | |||
Morphine glucuronidea | Ivermectina | Lysotracker greena | |||
Mycophenolic acid glucuronide | Losartan | Methotrexatea | |||
Paclitaxela | Methotrexatea | Mitoxantronea | |||
Phenobarbital glucuronide | Mitomycin Ca | Nucleoside analogsa | |||
Phenolphthalein sulfate | Opioid peptidesa | Pheophorbide αa | |||
2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) | Paclitaxela | PhIPa | |||
Phytoestrogen glucuronides | Rhodamine 123a | Pitavastatina | |||
Pravastatina | Ritonavira | Rhodamine 123a | |||
Probenecida | Saquinavira | Topotecana | |||
Resveratrol sulfatea | Teniposidea | ||||
Sulfinpyrazonea | Topotecana | ||||
Vinblastinea | Valinomycina | ||||
Zinc | Verapamila | ||||
Vinblastinea | |||||
Vincristinea |
↵a Demonstrated in ABC human transporter studies.