Selected substrates for recombinant human MRP2 and MRP3 assayed in vesicles
| Km | Reference(s) | |
|---|---|---|
| μM | ||
| MRP2 | ||
| Bisglucuronosyl bilirubin | 0.7 | Kamisako et al., 1999 |
| Monoglucuronosyl bilirubin | 0.9 | Kamisako et al., 1999 |
| Leukotriene C4 | 1.8 | Cui et al.,1999 |
| S-Glutathionyl 2,4-dinitrobenzene | 6.5 | Evers et al., 1998 |
| 17β-Glucuronosyl estradiol | 7.2 | Cui et al.,1999 |
| Cholyl-l-lysyl fluorescein | 3.3 | De Waart et al., 2010 |
| Fluo-3 | 3.7 | Nies et al., 1998; Cui et al., 2001a |
| Bromosulfophthalein | 12 | Cui et al., 2001a |
| MRP3 | ||
| Bisglucuronosyl bilirubin++ | Lee et al., 2004 | |
| Monoglucuronosyl bilirubin++ | Lee et al., 2004 | |
| 17β-Glucuronosyl estradiol | 26 | Zeng et al., 2000 |
| Dehydroepiandrosterone 3-sulfate | 46 | Lee et al., 2004 |
| Leukotriene C4 | 5.3 | Zeng et al., 2000 |
++, Substrate property proven, but no Km determined.