Methotrexate [Trexall] | Interferes with folate metabolism | Myelosuppression | SLC22A6 (OAT1)a SLC22A7 (OAT2)a SLC22A8 (OAT3)a,b SLC22A9 (OAT4)a SLCO1A2 (OATP1A2)a,b SLCO1B1 (OATP1B1)a,b,c SLCO1B3 (OATP1B3)a,b SLCO4C1 (OATP4C1)a SLC19A1 (RFC)a,c SLC46A1 (PCFT)a | (Abe et al., 1999; Sun et al., 2001; Takeda et al., 2002; Mikkaichi et al., 2004; Mori et al., 2004; Badagnani et al., 2006; van de Steeg et al., 2009, 2013; Zhao et al., 2009; Sowers et al., 2011) |
Mucositis |
Dermatological toxicity (skin rash and/or nail changes) |
Renal toxicity |
Neurotoxicity |