Rat body weight, liver weight, and plasma chemistries
Body weight, weight gain, liver weight, liver-to-body-weight ratios, and plasma chemistries are shown for rat NASH models. Data represent the mean ± S.E.M. from three to seven rats. Weight gain and loss are indicated by plus (+) and minus (−) signs, respectively.
| Parameter | Control | MCD | Atherogenic | fa/fa |
|---|---|---|---|---|
| Terminal body weight (g, n = 3) | 522.7 ± 9.0 | 308.0 ± 2.7 | 594.0 ± 24.2 | 733.3 ± 10.2 |
| Weight gain (g, n = 3) | +169.3 ± 7.5 | −47.0 ± 6.3* | +270.7 ± 18.0 | +205.0 ± 6.6 |
| Liver weight (g, n = 3) | 21.2 ± 0.3 | 16.1 ± 0.3 | 43.6 ± 1.9* | 38.3 ± 0.4* |
| Liver /body weight (%, n = 3) | 4.1 ± 0.1 | 5.2 ± 0.1 | 7.3 ± 0.0* | 5.2 ± 0.1 |
| Glucose (mg/dl, n = 4) | 157.5 ± 4.7 | 112.1 ± 7.3* | 159.3 ± 10.5 | 199.8 ± 11.1* |
| Insulin (ng/ml, n = 3) | 3.7 ± 0.9 | 1.3 ± 0.6 | 9.0 ± 2.5 | 28.6 ± 1.2* |
| ALT (U/l, n = 7) | 19.1 ± 1.1 | 136.1 ± 15.0* | 51.9 ± 5.5* | 53.5 ± 4.9* |
ALT, alanine aminotransferase.
↵* P ≤ 0.05 versus control rats.