TABLE 1

Pharmacokinetic parameters of 6β-OHF in wild-type and Oat3(−/−) mice.

Pharmacokinetic parameters of 6β-OHF were determined as described in Materials and Methods. Data were taken from Fig. 1.

	C_p,60-90min^{^a}	V_{urine,30-60min}	F_urine	CL_tot, ₆_β_-OHF	CL_renal,6_β_-OHF	C_p,90min	C_kidney	K_p,kidney
	nM	nmol/min/kg	%	ml/min/kg		nM
Wild type	122 ± 8	2.18 ± 0.17	33.5 ± 1.7	52.9 ± 4.0	18.1 ± 1.5	131 ± 17	217 ± 35	1.70 ± 0.18
Oat3(−/−)	152 ± 13	1.07 ± 0.23**	18.1 ± 3.7**	45.8 ± 3.73	7.60 ± 1.8**	161 ± 19	210 ± 27	1.30 ± 0.09^*

C_kidney, the kidney concentration at 90 minutes; C_{p, 60-90min}, mean plasma concentrations at 60 and 90 minutes; C_p,90min, plasma concentration at 90 minutes; F_urine, fractional urinary excretion ratio; K_p,kidney, kidney-to-plasma concentration ratio; V_{urine,30-60min}, mean urinary excretion rate at 60 and 90 minutes.
↵^a Mean value of the plasma concentrations at 60 and 90 minutes.
↵* P < 0.05; **P < 0.01.