Liver pathology scoring of NASH rodent models
NASH activity scores (NAS) were tabulated by summing the numerical grades of steatosis (0–3), inflammation (0–2), hepatocyte ballooning (0–2), and fibrosis (0–4) present within the liver. A total NAS score above 4 is a positive NASH diagnosis.
| Steatosis | Inflammation | Fibrosis | Ballooning | Total NAS | ||
|---|---|---|---|---|---|---|
| Rats | Control | 0 | 0.25 ± 0.06 | 0 | 0 | 0.25 ± 0.25 |
| MCD | 3 | 1 | 0.75 ± 0.06 | 0 | 4.75 ± 0.25 | |
| Atherogenic | 1.25 ± 0.06 | 1.25 ± 0.06 | 0.5 ± 0.07 | 0 | 4 ± 0.58 | |
| fa/fa | 1 | 0 | 0 | 0 | 1 | |
| Mice | Control | 1 ± 0.14 | 0 | 0 | 0 | 1 ± 0.58 |
| MCD | 2 | 1.25 ± 0.06 | 0 | 0 | 3.25 ± 0.25 | |
| Atherogenic | 2 | 0.75 ± 0.06 | 0.25 | 0 | 3 ± 0.41 | |
| ob/ob | 3 | 0.5 ± 0.07 | 0 | 0 | 3.5 ± 0.29 | |
| db/db | 3 | 1 | 0.5 ± 0.07 | 0 | 4.5 ± 0.29 |