TABLE 2

Pharmacokinetic parameters of midazolam in male cynomolgus monkeys (n = 5) following a single oral dose of 2 mg/kg midazolam before and after repeated dosing with 15 mg/kg/day rifampicin

Data are mean ± S.D.

Treatment Dayt1/2TmaxCmaxAUC0–taAUC0–∞
hng/mlh⋅ng/ml
Day 10.9 ± 0.11.5 ± 0.758.4 ± 24.3110 ± 34.1110 ± 34.3
Day 16b0.9 ± 0.21.1 ± 0.53.42 ± 1.186.09 ± 2.055.84 ± 1.79

  • ↵a AUC0–8 for day 1 and AUC0–4 for day 16.

  • ↵b Following 14 daily oral administrations of rifampicin from day 2 to day 15.