TABLE 6
Effect of anti-P450 mAbs on the formation of the aglycone of M9 in human liver microsomes
% Inhibition
Odanacatib 10
µ
M
Odanacatib 50
µ
M
mAb
Anti-CYP1A2
32.9
27.1
Anti-CYP2C
0.0
0.0
Anti-CYP2D6
0.0
0.0
Anti-CYP3A4
100
98.8