TABLE 1
Kinetic parameters of indiplon hydrolase activities
Enzyme
K
m
V
max
Cl
int
µM
pmol/min per mg protein
µl/min per mg protein
Human liver microsomes
179 ± 6.5
532 ± 16.0
3.0 ± 0.1
Recombinant AADAC
45.4 ± 2.3
374 ± 7.8
8.3 ± 0.3