Time point (h) | Subject | Mean | S.D. | |||||
---|---|---|---|---|---|---|---|---|
441 | 442 | 443 | 444 | 445 | 446 | |||
Urine | ||||||||
0–24 | 1.45 | 2.43 | 3.97 | 2.21 | 1.81 | 2.03 | 2.32 | 0.88 |
24–48 | 2.56 | 2.42 | 3.29 | 3.79 | 1.74 | 4.88 | 3.08 | 1.25 |
48–72 | 1.77 | 1.93 | 2.20 | 2.64 | 2.05 | 2.95 | 2.27 | 0.50 |
72–96 | 1.38 | 1.54 | 1.47 | 1.93 | 1.49 | 2.67 | 1.80 | 0.53 |
96–120 | 1.12 | 1.38 | 1.09 | 1.41 | 1.85 | 1.99 | 1.55 | 0.36 |
120–144 | 0.81 | 0.88 | 0.68 | 1.14 | 1.54 | 1.50 | 1.17 | 0.34 |
144–168 | 0.61 | 0.80 | 0.67 | 0.69 | 1.15 | 1.09 | 0.87 | 0.24 |
168–480 | 2.92 | 2.99 | 1.88 | 2.85 | 5.82 | 5.27 | 3.62 | 1.55 |
480–816 | 0.10 | BLQ | BLQ | NC | 0.78 | 0.26 | 0.19 | 0.31 |
Total | 12.7 | 14.4 | 15.3 | 16.7 | 18.2 | 22.6 | 16.9 | 3.8 |
Fecesa | ||||||||
0–24 | BLQ | 0.03 | BLQ | NS | NS | NS | 0.01 | 0.01 |
24–48 | 42.8 | 45.8 | NS | 20.2 | 0.25 | 24.4 | 26.7 | 18.5 |
48–72 | 16.0 | 10.1 | 13.5 | 16.6 | 3.34 | NS | 9.21 | 7.43 |
72–96 | 7.76 | 3.40 | NS | 25.7 | 9.17 | 23.2 | 13.8 | 10.0 |
96–120 | 4.13 | 2.76 | 1.78 | 6.59 | 17.4 | 5.10 | 7.20 | 5.87 |
120–144 | NS | 2.05 | NS | NS | NS | NS | 0.41 | 0.92 |
144–168 | 4.30 | 2.69 | 0.95 | 4.14 | 19.5 | 7.31 | 7.59 | 6.87 |
168–336 | 5.24 | 5.10 | 1.96 | 3.80 | 10.62 | 7.71 | 6.49 | 2.71 |
336–504 | 0.93 | 2.25 | 0.67 | 0.96 | 5.87 | 1.87 | 2.38 | 2.04 |
504–816 | 0.23 | 0.90 | BLQ | NC | 1.44 | 0.64 | 0.64 | 0.57 |
Total | 81.4 | 75.1 | 18.9 | 78.0 | 67.6 | 70.2 | 74.5 | 5.6 |
Urine + feces | 94.1 | 89.5 | 34.1 | 94.7 | 85.8 | 92.9 | 91.4 | 3.7 |
BLQ, below the limit of quantification; NC, no collection of sample (subject exited study); NS, no sample.
↵a The fecal recovery of subject 443 was significantly lower than for other subjects, and thus data for this subject were not included in the calculation of mean values. Two early samples (24–48 and 72–96 hours), in which a high percentage of the dose would be expected based on the pattern observed with the other subjects, were not available from this subject.