TABLE 2

Kinetic parameters (± S.D.) of time-dependent inhibition for ABT (0.014–10 mM) in the absence and presence of (S)-warfarin with diclofenac probe substrate

30-Minute Preincubation ConditionskinactKIkinact/KI
ABT(S)-Warfarin
mMμMmin−1mMml/min/mmol
0.014–1000.0826 ± 0.01573.49 ± 1.7223.7
0.20.0856 ± 0.00921.01 ± 0.2184.7
2.00.188 ± 0.0090.396 ± 0.047475
200.273 ± 0.0320.157 ± 0.0441740