TABLE 2

Pharmacokinetic parameters of odanacatib and radioactivity after an oral dose of [¹⁴C]odanacatib to healthy volunteers

Subject	Odanacatib				Radioactivity			Odanacatib:Radioactivity
Subject	AUC_0–∞	C_max	T_max	Apparent Terminal t_1/2	AUC_0–∞	C_max	T_max	AUC_0–∞	C_max
	μM · h	nM	h	h	μM · h	nM	h	Ratio	Ratio
441	16.91	214.0	12	89.1	34.10	241.0	12	0.50	0.89
442	26.12	218.9	8	150.3	41.30	258.0	24	0.63	0.85
443	17.39	314.5	5	92.0	33.00	337.0	5	0.53	0.93
444	15.34	261.3	12	81.9	37.10	299.0	12	0.41	0.87
445	21.13	174.2	24	86.1	39.50	206.0	24	0.53	0.85
446	22.38	281.8	24	105.5	46.40	346.0	24	0.48	0.81
AM	19.88	244.1	14.2	96.7^{^a}	38.57	281.2	16.8	0.51	0.87
S.D.	4.06	51.19	8.1	18.3^{^b}	4.96	55.57	8.3	0.07	0.04