Coenzyme | AKR1C30 | AKR1C31 | AKR1C32 | AKR1C33 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Km | kcat | kcat/Km | Km | kcat | kcat/Km | Km | kcat | kcat/Km | Km | kcat | kcat/Km | |
μM | min−1 | min−1μM−1 | μM | min−1 | min−1μM−1 | μM | min−1 | min−1μM−1 | μM | min−1 | min−1μM−1 | |
Reductase activity | ||||||||||||
NADPH | 0.8 | 14 | 18 | 0.8 | 3.4 | 4.2 | 0.7 | 1.7 | 2.4 | 5.4 | 4.6 | 0.85 |
NADH | 60 | 11 | 0.18 | 45 | 15 | 0.33 | 39 | 4.4 | 0.11 | NA | ||
Ratio | (0.01) | (1.3) | (100) | (0.02) | (0.2) | (13) | (0.02) | (0.4) | (22) | — | — | — |
Dehydrogenase activity | ||||||||||||
NADP+ | 1.1 | 26 | 24 | 0.6 | 7.7 | 13 | 1.0 | 8.1 | 8.1 | 17 | 51 | 3.0 |
NAD+ | 791 | 337 | 0.43 | 120 | 30 | 0.29 | 430 | 60 | 0.040 | 1400 | 4.1 | 0.003 |
Ratio | (0.001) | (0.08) | (56) | (0.005) | (0.3) | (44) | (0.002) | (0.1) | (203) | (0.01) | (12) | (1000) |
NA, no activity.