Pharmacokinetic parameter of loperamide
| Pharmacokinetic Parameters | No P-gp Modulator | Tariquidar 1.0 mg/kg | Elacridar 1.0 mg/kg | Elacridar 0.5 mg/kg+ Tariquidar 0.5 mg/kg | ||||
|---|---|---|---|---|---|---|---|---|
| Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | |
| Tmax (h) | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Cmax (ng/ml) | 5052 | 800 | 5371 | 660 | 5855 | 626 | 5756 | 252 |
| AUCinf (ng.h/ml) | 28900 | 4554 | 34365 | 4800 | 34409 | 4306 | 30627 | 3492 |
| t1/2 (h) | 3.6 | 0.3 | 3.9 | 0.5 | 4.9 | 0.7 | 4.2 | 0.2 |
| MRT (h) | 5.0 | 0.4 | 5.5 | 0.3 | 5.9 | 0.8 | 5.0 | 0.5 |
| Cl (ml/h/kg) | 4.4 | 0.7 | 3.7 | 0.5 | 3.4 | 0.5 | 4.2 | 0.5 |
| Vd (ml/kg) | 22.1 | 2.6 | 20.6 | 3.5 | 21.7 | 3.7 | 20.8 | 1.0 |
# ANOVA: Significantly different compared with the group that received no P-gp modulator.
## ANOVA: Significantly different compared with the group that received elacridar or tariquidar at 1.0 mg/kg.