Clinical Signs (1 h postdose) | No P-gp Modulator | Elacridar 1.0 mg/kg | Tariquidar 1.0 mg/kg | Elacridar 0.5 mg/kg+ Tariquidar 0.5 mg/kg | ||||
---|---|---|---|---|---|---|---|---|
N/n | Degree | N/n | Degree | N/n | Degree | N/n | Degree | |
Central nervous system | ||||||||
Lethargy | 0/12 | 0 | 6/12 | 2 | 4/12 | 2 | 9/12 | 3 |
Whole-body tetany | 0/12 | 0 | 0/12 | 0 | 0/12 | 0 | 9/12 | 2 |
Straub tail | 0/12 | 0 | 0/12 | 0 | 0/12 | 0 | 2/12 | 3 |
Piloerection | 0/12 | 0 | 4/12 | 1 | 3/12 | 1 | 7/12 | 2 |
Pulmonary | ||||||||
Shallow breathing | 0/12 | 0 | 5/12 | 2 | 2/12 | 1 | 9/12 | 3 |
Eyes | ||||||||
Eye protrusion | 0/12 | 0 | 0/12 | 0 | 0/12 | 0 | 5/12 | 2 |
Total score | 0 | 26 | 13 | 102 |
N/n, number of rats displaying these clinical signs/number of rats per group (n = 12).