Multivariate logistic analysis of the daily dose, lipophilicity, and being a P450 substrate, inhibitor, and inducer with DILI
The analysis is based on data shown in Supplemental Table 1. Daily dose, being a P450 substrate, inhibitor, and inducer, as well as lipophilicity were included in the model.
| Variable | Adjusted OR (95% CI) | P Value |
|---|---|---|
| High daily dose (≥100 mg) | 7.10 (3.36–15.0) | <0.0001 |
| Being a P450 substrate | 5.04 (2.34–10.9) | <0.0001 |
| Being a P450 inhibitor | 1.11(0.49–2.51) | 0.7943 |
| Being a P450 inducer | 1.21 (0.43–3.38) | 0.7143 |
| High lipophilicity (logP ≥3) | 1.22 (0.58–2.58) | 0.5927 |