TABLE 1

Inhibition of CYP2C9: IC50 values (± S.D.) for ABT, (S)-warfarin, and diclofenac incubated discretely and ABT incubated with either (S)-warfarin or diclofenac

Probe Substrate (Km; Incubation Concentration)Inhibitor + Coincubated Analyte (Concentration)Concentration Range of InhibitorIC50
μM
Diclofenac (5 μM)ABT0–10,0005320 ± 1080
ABT + (S)-Warfarin (2 μM)0–10,0001210 ± 259
(S)-Warfarin0–1006.28 ± 2.39
(S)-Warfarin (2 μM)ABT0–10,000370 ± 12
ABT + Diclofenac (5 μM)0–10,000394 ± 61
Diclofenac0–10016.9 ± 5.0