Relative distribution of metabolites in urine from mice, rats, dogs, and humans after oral administration of [14C]canagliflozin
| Metabolite Identification | %Dosea | |||||
|---|---|---|---|---|---|---|
| Mouse (100 mg/kg) | Rat (3 mg/kg) | Dog (4 mg/kg) | Human (188 mg) | |||
| Male | Female | Male | Female | Male | Male | |
| Canagliflozin | 0.3 | 0.2 | 0.2 | 0.3 | 0.3 | ND |
| M1 | 0.7 | 0.1 | ND | ND | ND | ND |
| M2 | 0.3 | ND | ND | ND | ND | ND |
| M4 | ND | 0.4 | ND | ND | 0.4 | ND |
| M5 | ND | 0.1 | ND | ND | ND | 13.7 |
| M6 | ND | ND | 0.9 | 0.4 | ND | ND |
| M7 | 1.3 | 1.1 | ND | ND | ND | 18.2 |
| M8 | 0.2 | 1.0 | 2.7 | 4.1 | 0.8 | ND |
| M9 | 2.3 | 3.3 | 0.4 | 0.6 | 0.5 | ND |
| Total | 5.1 | 6.2 | 4.0 | 5.3 | 2.0 | 31.9 |
ND, not detected.
↵a Urine samples pooled over 0–48 h.