Percentage of radioactive dose recovery in mice, rats, dogs, and humans
| Species | Sex | No. of Subjects | Dose | Collection Interval (h) | %Radioactive Dose | |||
|---|---|---|---|---|---|---|---|---|
| Urine | Bile | Feces | Total | |||||
| Intact mouse | Male | 4 | 100 mg/kg | 96 | 5.81 | NA | 91.8 | 97.8 |
| Female | 4 | 100 mg/kg | 96 | 6.46 | NA | 91.7 | 98.3 | |
| BDC mouse | Male | 5 | 100 mg/kg | 24 | N.A. | 49.1 | NA | NA |
| Intact rat | Male | 4 | 3 mg/kg | 120 | 4.0 | NA | 88.5 | 96.9 |
| Female | 4 | 3 mg/kg | 120 | 5.14 | NA | 89.9 | 98.4 | |
| BDC rat | Male | 3 mg/kg | 24 | 3.71 | 52.2 | 22.4 | 78.3 | |
| Dog | Male | 3 | 4 mg/kg | 144 | 1.9 | NA | 93.6 | 99.1 |
| Human | Male | 6 | 188 mg | 168 | 32.5 | NA | 60.4 | 92.9 |
BDC, bile duct-cannulated; NA, not applicable.