Cumulative recovery of administered radioactivity in urine, bile, and feces collected from rats after a single oral dose of GNE-892 at 15 mg/kg (100 µCi/kg)
| Time Period (h) | Cumulative Recovery of Dose (%) | ||||||
|---|---|---|---|---|---|---|---|
| Bile Duct–Intact Rats (Mean, n = 3) | Bile Duct–Cannulated Rats (Mean, n = 3) | ||||||
| Urine | Feces | Total | Urine | Feces | Bile | Total | |
| 0–8 | 15.3 | 0.0 | 15.3 | 28.2 | 0.0 | 48.7 | 76.9 |
| 0–24 | 17.3 | 74.2 | 91.5 | 32.1 | 8.4 | 52.3 | 92.8 |
| 0–48 | 17.6 | 77.0 | 94.6 | 32.4 | 10.5 | 53.0 | 95.9 |
| 0–72 | 17.7 | 77.2 | 94.9 | 32.5 | 10.7 | 53.1 | 96.3 |
| 0–96 | 17.7 | 77.3 | 95.0 | 32.5 | 10.8 | 53.1 | 96.4 |
| 0–120 | 17.8 | 77.3 | 95.1 | — | — | — | — |
| 0–144 | 17.8 | 77.4 | 95.2 | — | — | — | — |
| 0–168 | 17.8 | 77.4 | 95.2 | — | — | — | — |