TABLE 3.

Noncompartmental pharmacokinetic parameters of apicidin after portal venous, superior mesenteric arterial, and intra-arterial injection of apicidin (2 mg/kg) in anesthetized rats (mean ± S.D.).

ParametersPortal Venous Injection
(n = 5)Mesenteric Arterial Injection
(n = 5)Intra-arterial Injection
(n = 5)
t1/2 (h)1.9 ± 0.31.4 ± 0.51.3 ± 0.4
C0 (ng/ml)957.8 ± 384.0a799.7 ± 180.61616.7 ± 418.3
AUC∞ (ng·h/ml)891.1 ± 155.3a632.0 ± 72.5b1233.3 ± 84.4
CLs (ml/min/kg)38.6 ± 8.3a53.4 ± 6.8b27.1 ± 2.0
Vss (l/kg)5.5 ± 1.4a4.9 ± 1.12.3 ± 0.5
MRT∞ (h)2.4 ± 0.61.6 ± 0.4b1.4 ± 0.4

  • ↵a P < 0.05 versus i.v. injection.

  • ↵b P < 0.05 versus portal venous injection.