Summary of mean atorvastatin blood AUC (±S.D.) when administered 5 mg/kg i.v. in the absence and presence of 20 mg/kg i.v. rifampin or 35 mg/kg oral ketoconazole in various animal models (N = 3); *P < 0.05
| Blood AUC (µM × hour) | Wild Type | Cyp3a Knockout | Oatp1a/1B Knockout |
|---|---|---|---|
| Vehicle | 0.957 (0.385) | 1.27 (0.30) | 1.66 (0.56) |
| Rifampin | 7.01 (4.89)* | 3.45 (0.66)* | 8.56 (6.3)* |
| Ketoconazole | 2.07 (1.47) | 1.56 (0.19) | 3.13 (0.36)* |